By Ellen Heber - Katz , : I : Ronald
نویسندگان
چکیده
It is generally believed (1-3) that T lymphocytes recognize antigen in association with products of the major histocompatibility complex (MHC).I If we consider T cell responsiveness in terms of a recognition unit, it would be made up of three components: antigen, a T cell receptor (s), and a surface Ia molecule on an antigenpresenting cell (APC). In such a model, lack of responsiveness (Ir gene defects) could be explained by a defect of either antigen-Ia, antigen-receptor, or Ia-receptor interaction, or any combination of these. An understanding of these MHC-associated Ir gene defects as well as the mechanism of antigen-induced T cell activation requires the ability to examine the contribution of each component separately by holding the other two components constant. We encountered a unique opportunity to explore this issue using T cell clones specific for cytochrome c. In investigating the T cell responses of B10.A and B10.A(5R) mice to a family of cytochrome c peptides, it was found that these two strains, differing only in the K region, and I-A and L B subregions of the MHC, each had a characteristic pattern of responsiveness to a given set of cytochrome c cyanogen bromide cleavage fragments (4-6). When T cell clones were derived from either of these cytochrome c-immune animals and tested for antigen specificity, the response profiles of the clones closely resembled those of the whole lymph node population. Remarkably, however, the clones from either strain responded to antigen on both B10.Aand B10.A(5R)presenting cells. Furthermore, the response pattern of either set of clones resembled that of the whole B10.A lymph node population when B10.A-presenting cells were
منابع مشابه
Mapping of genes involved in murine herpes simplex virus keratitis: identification of genes and their modifiers.
Herpes simplex keratitis (HSK) is an inflammatory response to viral infection and self antigens in the cornea and is a major cause of blindness. Using two strains of mice which are susceptible (129/SVEV) and resistant (C57BL/6) to herpes simplex virus (HSV) strain KOS, (129/SVEV x C57BL/6)F(2) mice were generated and examined for their disease susceptibility in terms of clinical symptoms, ocula...
متن کاملRegeneration of Mammalian Body Parts
Miracle mice When, in 1994, Dr Ellen Heber-Katz of the Wistar Institute in Philadelphia was monitoring marked mice in a group that she used as experimental animals in connection with her research on multiple sclerosis, she received a surprise. The marked mice could not be found! They had punch holes in the ears for identification, and at first it seemed as though a mistake had been made, for no...
متن کاملPatrilocality and Missing Women
Recent scholarship has documented an alarming increase in the sex ratio at birth in parts of East Asia, South Asia and the South Caucuses. I argue that parents engage in sex selection because of patrilocal norms that dictate elderly coresidence between parents and sons. Sex ratios and coresidence rates are positively correlated when looking across countries, within countries across districts, a...
متن کاملBasal and insul in human must n-mediated carbohydrate metabolism .e deficient in phosphofructokinase I
ABRAM KATZ, MARK K. SPENCER, STEPHEN LILLIOJA, ZHEN YAN, DAVID M. MOTT, RONALD G. HALLER, AND STEVEN F. LEWIS Department of Kinesiology, University of Illinois, Urbana, Illinois 61801; Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016; Departments of Physiology and Neurology, University ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2003